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Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Detection of swine hepatitis E virus in the porcine hepatic lesion in Jeju Island | J. Vet. Set. 2007 8 1 51-55 JOURNAL OF Veterinary Science Detection of swine hepatitis E virus in the porcine hepatic lesion in Jeju Island Song-Hak Lee1 Sang-Chul Kang1 Dae-Yong Kim2 Jong-Hee Bae1 Jae-Hoon Kim1 1 Department of Veterinary Medicine Cheju National University Jeju 690-756 Korea Department of Veterinary Pathology College of Veterinary Medicine Seoul National University Seoul 151-742 Korea Swine hepatitis E virus HEV is an emerging zoonotic pathogen due to its close genomic similarity to human HEV. The prevalence of swine HEV in the hepatic lesion of pigs from the Jeju Island was investigated by reverse transcriptase polymerase chain reaction RT-PCR . In total 40 pigs with hepatitis lesions were selected from 19 different farms based on examination by microscopy. RT-PCR findings revealed swine HEV in 22 cases 55 including 18 suckling pigs and 4 growing pigs. Several histopathological lesions including multifocal lympho-plasmacytic hepatitis portal inflammation and focal hepatocellular necrosis were observed in liver sections of swine HEV PCR-positive pigs. The present study suggests that the prevalence of swine HEV is very high in the pig population in Jeju Island and that pigs are infected at early stages of growth under 2 months of age . The high prevalence of swine HEV in pigs in Jeju Island and the ability of this virus to infect across species puts people with swine-associated occupations at possible risk of zoonotic infection. Key words Jeju Island liver pig RT-PCR swine hepatitis E virus Introduction Hepatitis E virus HEV is an enterically transmitted causative agent of acute non-A non-B and icterus-inducing hepatitis in humans 21 HEV is a nonenveloped small virus with an approximately 7.5 kb single-stranded positive sense RNA genome containing 3 open reading frames. Based on its structural and physiochemical properties HEV was provisionally classified as part of the family Caliciviridae genus Calicivirus. Recently the virus was reclassified in .
