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Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Protective and therapeutic effects of an extract mixture of alder tree, labiate herb, milk thistle green bean-rice bran fermentation, and turnip against ethanol-induced toxicity in the rat | J. Vet. Sci. 2008 9 1 31-37 JOURNAL OF Veterinary Science Protective and therapeutic effects of an extract mixture of alder tree labiate herb milk thistle green bean-rice bran fermentation and turnip against ethanol-induced toxicity in the rat 1 1 1 1 2 3 Min-Won Baek Seung-Hyeok Seok Hui-Young Lee Dong Jae Kim Byoung-Hee Lee Young-Tae Ahn Kwang-Sei Lim3 Chul-Sung Huh3 Jae-Hak Park1 Department of Laboratory Animal Medicine College of Veterinary Medicine Seoul National University Seoul 151-742 Korea 2Department of Animal Experimentation College of Medicine Seoul National University Seoul 110-799 Korea 3Dairy Product Research Team Korea Yakult R D Center Yongin 446-901 Korea An herbal extract mixture and yogurt added to the herbal extract mixture were tested for their protective and therapeutic effects on ethanol-induced liver injury. The herbal extract mixture yogurt and commercial drugs were used for treatment for two weeks prior to administering a single oral dose of ethanol 3 g kg body weight . The herbal extract mixture and yogurt added to the herbal extract mixture were found to provide protection against ethanol-induced toxicity comparable to the commercial drug treatment according to the serum and histopathological analysis. It was also shown that co-treatment with herbal extract mixture and yogurt against a triple oral dose of ethanol 2 g kg body weight over one week provided protection against ethanol toxicity. After the initial set of experiments the herbal extract mixture and yogurt treatments were extended for three more weeks. When compared to the positive control further treatment with both the herbal extract and yogurt significantly reduced liver injury and resulted in a lower grade of lipid deposition. Keywords ethanol-induced toxicity herbal extract mixture protective effect rat yogurt Introduction Functional foods and food additives are substances that provide health benefits beyond basic nutrition due to certain physiologically active components.
