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Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Tactics of Mycobacterium avium subsp. paratuberculosis for intracellular survival in mononuclear phagocytes | J. Vet. Sci. 2008 9 1 1-8 JOURNAL OF Review Veterinary Science Tactics of Mycobacterium avium subsp. paratuberculosis for intracellular survival in mononuclear phagocytes Seng-Ryong Woo Charles J. Czuprynski Department of Pathobiological Sciences School of Veterinary Medicine University of Wisconsin-Madison Madison WI 53 706 USA Johne s disease is a condition that refers to chronic granulomatous enteritis in ruminants. It is believed that survival and replication of Mycobacterium M. paratuberculosis in mononuclear phagocytes plays an important role in the pathogenesis of Johne s disease. However it is not clear how M. paratuberculosis survives for long time periods in mononuclear phagocytes nor is it clear which factors trigger multiplication of these bacilli and result in the development of Johne s disease. Investigating the intracellular fate of M. paratuberculosis is challenging because of its very slow growth more than two months to form visible colonies on media . Existing animal models also have limitations. Despite those obstacles there has been progress in understanding the intracellular survival tactics of M. paratuberculosis and the host response against them. In this review we compare known aspects of the intracellular survival tactics of M. paratuberculosis with those of other mycobacterial species and consider possible mycobactericidal mechanisms of mononuclear phagocytes. Keywords intracellular Johne s disease Mycobacterium avium Mycobacterium paratuberculosis Introduction Mycobacterium M. paratuberculosis is the etiologic agent of chronic enteritis of ruminants known as paratuberculosis or Johne s disease 14 .M. paratuberculosis is a Gram-positive acid-fast bacillus that belongs to the M. avium complex 10 . It grows very slowly and requires mycobactin J an iron-chelating cell wall component produced by most other mycobacteria for growth in vitro. As a result visible colony formation takes 8 to 12 weeks or longer. Identification of M. paratuberculosis