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Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Polysaccharides isolated from Phellinus gilvus enhances dermal wound healing in streptozotocin-induced diabetic rats | J. Vet. Sci. 2005 6 2 161-164 JOURNAL OF Short Communication Veterinary Science Polysaccharides isolated from Phellinus gilvus enhances dermal wound healing in streptozotocin-induced diabetic rats Jae-Sung Bae Kwang-Ho Jang Hee-Kyung Jin College of Veterinary Medicine KyungpookNational University Daegu 702-701 Korea Dermal wound healing is a complex process that involved inflammation leading to re-epithelialization granulation tissue and tissue remodeling. Previous studies from our laboratory have shown that polysaccharides isolated from fungus Phellinus gilvus PG have various anti-inflammatory activities. In present study we have assessed the effect of polysaccharides from PG on the dermal wound healing of polysaccharides from PG in streptozotocin-induced diabetic rat model. Six of 6-mm circular wounds were created with biopsy punch on the 4th day after induction of diabetes. After 24 hours each test substance was applied to the wound twice a day for next 5 days. Circular wounds treated with PG showed significantly reduced wound contraction and complete re-epithelialization as compared to wounds of non-treated p 0.05 . These results show that polysaccharides isolated from PG enhanced wound repair in diabetic impaired healing and could be developed as a wound healing agent in such clinical settings. Key words diabetes Phellinus gilvus polysaccharides rat wound healing Tissue repair and wound healing are complex processes involving inflammation re-epithelialization neovascularization fibroplasia and wound contraction 8 . In the normal host wound healing is usually uncomplicated and proceeds at a rapid rate. In contrast most healing failures are associated with some form of host impairment including diabetes infection immunosuppression obesity or malnutrition 14 . Among them diabetes probably represents the prototype of impaired healing model since contribution of impairment such as peripheral vascular disease and lowered immunity against infections. Therefore we .
