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Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Alteration of nitrergic neuromuscular transmission as a result of acute experimental colitis in rat | J. Vet. Set. 2006 7 2 151-155 JOURNAL OF Veterinary Science Influence of endotoxin induced fever on the pharmacokinetics of intramuscularly administered cefepime in rabbits Ayman Goudah Samar M. Mouneir1 Jae-Han Shim2 A. M. Abd El-Aty12 department of Pharmacology Faculty of Veterinary Medicine Cairo University 12211-Giza Egypt natural Products Chemistry Laboratory Division of Applied Bioscience and Biotechnology College of Agriculture and Life Science Chonnam National University Gwangju 500-757 Korea This study examined the effect of experimentally induced fever on the pharmacokinetics of cefepime 75 mg kg BW administered intramuscularly to six rabbits. The study was carried out in two consecutive phases separated by a two-week washout period. An infection was induced by an intravenous inoculation of 5 X 108 colony-forming units of Escherichia coll 24 h before the pharmacokinetic investigation. A quantitative microbiological assay was employed to measure the plasma cefepime concentrations using an agar-gel diffusion method with Bacillus subtilis ATCC 6633 as the test organism. Twenty-four hour after the injection the rectal temperature in the infected animals increased by rc. There was a significant reduction in the elimination halflife by 21.8 in the febrile rabbits compared to healthy animals. In addition the infection significantly increased the peak plasma concentrations by 11.9 the mean residence time by 19.9 the area under the plasmaconcentration-time curve by 53.6 and the area under the moment curve by 62.3 . In conclusion the endotoxin-induced febrile state produced significant changes in the plasma levels as well as some of the pharmacokinetic variables of cefepime in rabbits. Key words cefepime microbiological assay pharmacokinetics rabbits Introduction Cefepime a molecular formula of C I Ì25CIN6O5S2IÌCII i2O and a molecular weight of 571.5 is a parenteral fourthgeneration cephalosporin antibiotic with a wide spectrum of antimicrobial activity and a .