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Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Changes in orexin-A and neuropeptide Y expression in the hypothalamus of the fasted and high-fat diet fed rats | J. Vet. Sci. 2004 5 4 295-302 JOURNAL OF Veterinary Science Changes in orexin-A and neuropeptide Y expression in the hypothalamus of the fasted and high-fat diet fed rats Eun Sung Park1 Seong Joon Yi2 Jin Sang Kim3 Heungshik S. Lee1 In Se Lee1 Je Kyung Seong1 Hee Kyung Jin2 Yeo Sung Yoon1 Department of Veterinary Anatomy and Cell Biology College of Veterinary Medicine and Agricultural Biotechnology Seoul National University Seoul 151-742 Korea College of Veterinary Medicine Kyungpook National University Daegu 702-701 Korea Department of Physical Therapy College of Rehabilitation Daegu University Daegu 705-714 Korea This study was aimed to investigate the changes of orexin-A OXA and neuropeptide Y NPY expression in the hypothalamus of the fasted and high-fat diet fed rats. For the experiments the male Sprague-Dawley SD rats were used as the model of high-fat diet-induced obesity. The mean loss of body weight MLBW did not show the linear pattern during the fasting from 24 h to 84 h of fastings the MLBW was not significantly changed. The numbers of OXA-immunoreactive IR neurons were decreased at 84 h of fasting compared with those in other five fasting subgroups. The NPY immunoreactivities in the arcuate nucleus ARC and the suprachiasmatic nucleus SCN observed at 84 h of fasting were higher than that observed at 24 h of fasting. The number of OXA-IR neurons of the LHA lateral hypothalamic area in the high-fat HF diet fed group was more increased than that of the same area in the normal-fat NF diet fed group. The NPY immunoreactivities of the ARC and the SCN were higher in HF group than those observed in the same areas of NF group. Based on these results it is noteworthy that the decrease of the body weight during the fast was not proportionate to the time-course implicating a possible adaptation of the body for survival against starvation. The HF diet might activate the OXA and the NPY in the LHA to enhance food intake. Key words Arcuate nucleus fasting .
