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Các biến chứng và phản ứng bất lợi tiềm năng phản ứng da tạm thời [23], bao gồm đỏ, phản ứng sưng u hạt địa phương, nhiễm khuẩn, acneiform, và các tổn thương nang. Quá mẫn cảm, mặc dù giảm sau khi giới thiệu nhiều hơn tinh khiết nguyên liệu axit hyaluronic liệu [24]. Tuy nhiên, không có vấn đề dài hạn [9] | Soft Tissue Augmentation Chapter 6 101 Table 6.3. Continued Implants Indications Treatment Complications and potential adverse reactions Restylane Hyaluronic acid derived from bacterial biofermentation process Perlane 20 mg ml stabilized hyaluronic acid with approximately 10 000 gel par-ticles ml is recommended for nasolabial folds and lips fullness and pouting Restylane 20 mg ml stabilized hyaluronic acid with approximately 100 000 gel particles ml is recommended for rhytids such as glabellar oral commissures. Lips fullness pouting and vermilion border Restylane fine lines 20 mg ml stabilized hyaluronic acid with approximately 200 000 gel particles ml is recommended for thin superficial lines such as worry lines periorbital lines perioral lines FDA-approved 9 Perlane Injected into the deep layer of the dermis and or surface layer of the subcutis Restylane Injected into the mid part of the dermis Restylane fine lines Injected into upper part of the dermis Temporary skin reactions 23 including redness swelling localized granulomatous reactions bacterial infection acneiform and cystic lesions. Hypersensitivity although declining after introduction of more purified hyaluronic acid raw material 24 . However no long-range problems 9 Juvederm 18 24 30 Viscoelastic nonanimal hyaluronic acid gel 18 mg g designed for the superficial dermis specifi cally for fine lines and rhytids 24 mg g designed for the mid dermis specifically for deeper rhytids 30 mg g designed for the mid to deep dermis specifically for deeper furrows such as nasolabials and for lip and cheek augmentation. Not available in the USA. Outside the USA approved for a wide range of facial applications from lip augmentation and superficial lines to frown lines and deep rhytids 25 None of the three should be overcorrected.Various injection techniques apply depending on the type of correction and product used. These techniques include linear threading serial puncture fanning and cross-hatching 23 The first is .