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Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí hóa học quốc tế đề tài : Identification of symptom domains in ulcerative colitis that occur frequently during flares and are responsive to changes in disease activity | BioMed Central Health and Quality of Life Outcomes Research Identification of symptom domains in ulcerative colitis that occur frequently during flares and are responsive to changes in disease activity Joel C Joyce1 Akbar K Waljee2 Tahira Khan2 Patricia A Wren3 Maneesh Dave4 Ellen M Zimmermann2 Sijian Wang5 Ji Zhu5 and Peter DR Higgins 2 Open Access Address 1Medical School University of Michigan Ann Arbor MI USA 2Division of Gastroenterology Department of Internal Medicine University of Michigan Ann Arbor MI USA 3School of Health Sciences Oakland University Rochester MI USA 4School of Public Health University of Michigan Ann Arbor MI USA and 5Department of Statistics University of Michigan Ann Arbor MI USA Email Joel C Joyce - joeljz@umich.edu Akbar KWaljee - awaljee@med.umich.edu Tahira Khan - Tahira.Khan@pfizer.com Patricia A Wren - wren@oakland.edu Maneesh Dave - maneesh@umich.edu Ellen M Zimmermann - ezimmer@umich.edu Sijian Wang - sijwang@umich.edu Ji Zhu - jizhu@umich.edu Peter DR Higgins - phiggins@umich.edu Corresponding author Published 20 September 2008 Received 7 May 2008 Health and Quality of Life Outcomes 2008 6 69 doi 10.1186 1477-7525-6-69 Accepted 20 September 2008 This article is available from http www.hqlo.cOm content 6 1 69 2008 Joyce et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Ulcerative colitis disease activity is determined by measuring symptoms and signs. Our aim was to determine which symptom domains are frequent and responsive to change in the evaluation of disease activity which are those defined by three criteria I they occur frequently during flares 2 they improve during effective
