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We planned the first edition of this book on a ‘need to know’ basis, its primary object being to provide students and medical and dental practitioners with the knowledge essential for an informed approach to the prevention and treatment of viral infections. We aimed also at supplying just enough basic virology to underpin the more practical aspects—clinical manifestations, epidemiology, pathogenesis, immune responses, and so forth. And not least, we tried our best to make the text as readable as is possible, given the highly technical nature of some of the material. The success of Human Virology prompted us to produce a second edition, which, in view of the accelerating pace of advance. | HV3E_Prel i-xviii 5 5 06 5 17 PM Page i Human Virology HV3E_Prel i-xviii 5 5 06 5 17 PM Page ii Oxford University Press makes no representation express or implied that the drug dosages in this book are correct. Readers must therefore always check the product information and clinical procedures with the most up-to-date published product information and data sheets provided by the manufacturers and the most recent codes of conduct and safety regulations. The authors and the publishers do not accept responsibility or legal liability for any errors in the text or for the misuse or misapplication of material in this work. HV3E_Prel i-xviii 5 5 06 5 17 PM Page iii Human Virology A text for students of medicine dentistry and microbiology Third edition Leslie Collier Emeritus Professor of Virology University of London and John Oxford Professor of Virology Scientific Director of Retroscreen Virology Ltd Professor of Virology at St Bartholomew s and The Royal London Hospital Queen Mary s School of Medicine and Dentistry With illustrations by Jim Pipkin OXFORD UNIVERSITY .