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Micro-organisms are mostly harmless, non-pathogenic, and indeed may be beneficial. It is estimated that a human body has about 10" cells, but only 10% of these are human in origin; the rest is almost entirely microbial flora. Medical microbiology is the study of microscopic organisms and their effect on man. It encompasses their biology, diagnosis, treatment and prevention. | Medical Microbiology made memorable Steven H. M y i n t MD MRCP DipClinMicro Professor of Clinical Microbiology University of Leicester Medical School Leicester UK Simon Kilvington PhD Clinical Scientist Public Health Laboratory Leicester UK Anthony Maggs MBPhDMRCPath Clinical Lecturer University of Leicester Medical School Leicester UK R Andrew Swa n n MA BM BCh FRCPath Consultant Microbiologist Leicester Royal Infirmary Leicester UK Contents III Principles of infectious disease 1. Introduction to micro-organisms 2 2. Viruses - the basic facts 4 3. Bacteria - the basic facts 6 4. Fungi - the basic facts 8 5. Protozoa -the basic facts 10 6. Helminths - the basic facts 12 7. Viroids prions and virinos 14 Short answer questions I Basic microbiology 16 8. Epidemiology of infectious diseases 18 9. Pathogenesis of infectious disease 20 10. Pathology of infectious disease 22 11. Innate host defences to infectious disease 24 12. Adaptive host response to infectious disease 26 Short answer questions 2 Immunity to infection 28 13. Diagnosis of infectious disease 30 Diseases caused by micro-organisms 14. Upper respiratory tract infections 34 15. Lower respiratory tract infections 36 16. Meningitis 38 Case study 1 40 17. Encephalitis and other nervous system infections 42 18. Eye infections 44 19. Viral skin rashes 46 20. Cutaneous infections - bacterial and fungal 48 21. Gastrointestinal infections 50 22. Hepatitis and pancreatitis 52 23. Infections of the heart 54 24. Urinary tract infections 56 25. Genital tract infections 58 Case study 2 60 26. Obstetric and neonatal infections 62 27. Infections of bone joints and muscle 64 28. Septicaemia 66 Case study 3 68 29. Acquired immunodeficiency syndrome AIDS 70 30. Infectious mononucleosis and other systemic infections 72 31. Infections of the immunocompromised host 74 32. Zoonoses 76 Case study 4 78 33. Malaria 80 Case study 5 82 34. Other tropical infections 84 35. Pyrexia of unknown origin 88 36. New and re-emerging .