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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Asymmetric histone modifications between the original and derived loci of human segmental duplications. | Open Access Asymmetric histone modifications between the original and derived loci of human segmental duplications Deyou Zheng Address Institute for Brain Disorders and Neural Regeneration The Saul R. Korey Department of Neurology Albert Einstein College of Medicine Rose F. Kennedy Center 915B 1410 Pelham Parkway South Bronx NY 10461 USA. Email dzheng@aecom.yu.edu Published 3 July 2008 Genome Biology 2008 9 R105 doi 10.1186 gb-2008-9-7-r105 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2008 9 7 R105 Received 13 May 2008 Revised 23 June 2008 Accepted 3 July 2008 2008 Zheng licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Sequencing and annotation of several mammalian genomes have revealed that segmental duplications are a common architectural feature of primate genomes in fact about 5 of the human genome is composed of large blocks of interspersed segmental duplications. These segmental duplications have been implicated in genomic copy-number variation gene novelty and various genomic disorders. However the molecular processes involved in the evolution and regulation of duplicated sequences remain largely unexplored. Results In this study the profile of about 20 histone modifications within human segmental duplications was characterized using high-resolution genome-wide data derived from a ChIP-Seq study. The analysis demonstrates that derivative loci of segmental duplications often differ significantly from the original with respect to many histone methylations. Further investigation showed that genes are present three times more frequently in the original than in the derivative whereas pseudogenes exhibit the opposite trend. These asymmetries
