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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: The telosome/shelterin complex and its functions. | Review The telosome shelterin complex and its functions Huawei Xin Dan Liu and Zhou Songyang Addresses Verna and Marrs McLean Department of Biochemistry and Molecular Biology Baylor College of Medicine Baylor Plaza Houston TX 77030 USA. fCell-Based Assay Screening Service Core Baylor College of Medicine Houston TX 77030 USA. Correspondence Zhou Songyang. Email songyang@bcm.edu Published 18 September 2008 Genome Biology 2008 9 232 doi 10.1186 gb-2008-9-9-232 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2008 9 9 232 2008 BioMed Central Ltd Abstract The telomeres that cap the ends of eukaryotic chromosomes serve a dual role in protecting the chromosome ends and in intracellular signaling for regulating cell proliferation. A complex of six telomere-associated proteins has been identified - the telosome or shelterin complex - that is crucial for both the maintenance of telomere structure and its signaling functions. Telomeres are specialized structures at the ends of eukaryotic chromosomes that help to maintain genome integrity in eukaryotes by preventing chromosomal rearrangements or chromosomes fusing to each other and by enabling complete replication of the ends of the linear DNA molecules. Telomeric DNA is composed of a series of sequence repeats and terminates in a 3 single-stranded ss DNA overhang. At each round of DNA replication the telomeric DNA becomes shorter but it can be regenerated by the enzyme telomerase an RNA-containing DNA polymerase. Both the double and single-stranded telomeric DNA is bound and protected by DNA-binding proteins that in turn associate with other signaling proteins complexes to achieve telomere-end protection and length control. The length of telomeric DNA is maintained by the enzyme telomerase but in addition six telomere-associated proteins - TRF1 TRF2 POT1 RAP1 TIN2 and TPP1 in mammalian cells - have been shown to form a complex known as the telosome or shelterin .
