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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Chromatin Central: towards the comparative proteome by accurate mapping of the yeast proteomic environment. | Research Open Access Chromatin Central towards the comparative proteome by accurate mapping of the yeast proteomic environment Anna Shevchenko Assen Rogiiev Daniel Schaft Luke Buchanan Bianca Habermann Cagri Sakalar Henrik Thomas Nevan J Krogan Andrej Shevchenko and A Francis Stewart Addresses MPI of Molecular Cell Biology and Genetics Pfotenhauerstrasse 108 01307 Dresden Germany. Genomics BioInnovationsZentrum Technische Universitat Dresden Am Tatzberg 47-51 01307 Dresden Germany. Department of Cellular and Molecular Pharmacology University of California San Francisco 1700 4th Street San Francisco CA 94158 USA. Correspondence Andrej Shevchenko. Email shevchenko@mpi-cbg.de. A Francis Stewart. Email stewart@biotec.tu-dresden.de Published 28 November 2008 Genome Biology 2008 9 R167 doi 10.1186 gb-2008-9- 11-r167 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2008 9 11 R167 Received 29 July 2008 Revised 21 October 2008 Accepted 28 November 2008 2008 Shevchenko et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Understanding the design logic of living systems requires the understanding and comparison of proteomes. Proteomes define the commonalities between organisms more precisely than genomic sequences. Because uncertainties remain regarding the accuracy of proteomic data several issues need to be resolved before comparative proteomics can be fruitful. Results The Saccharomyces cerevisiae proteome presents the highest quality proteomic data available. To evaluate the accuracy of these data we intensively mapped a proteomic environment termed Chromatin Central which encompasses eight protein complexes including the major histone .
