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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: GOTax: investigating biological processes and biochemical activities along the taxonomic tree. | Open Access Software GOTax investigating biological processes and biochemical activities along the taxonomic tree Andreas Schlicker Jorg Rahnenfuhrer Mario Albrecht Thomas Lengauer and Francisco S Domingues Address Department of Computational Biology and Applied Algorithmics Max-Planck-Institute for Informatics Stuhlsatzenhausweg 66123 Saarbrucken Germany. Correspondence Andreas Schlicker. Email schlandi@mpi-inf.mpg.de Published 8 March 2007 Genome Biology 2007 8 R33 doi 10.1 186 gb-2007-8-3-r33 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2007 8 3 R33 Received 23 October 2006 Revised 18 January 2007 Accepted 8 March 2007 2007 Schlicker et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract We describe GOTax a comparative genomics platform that integrates protein annotation with protein family classification and taxonomy. User-defined sets of proteins protein families annotation terms or taxonomic groups can be selected and compared allowing for the analysis of distribution of biological processes and molecular activities over different taxonomic groups. In particular a measure of functional similarity is available for comparing proteins and protein families establishing functional relationships independent of evolution. Rationale New opportunities for understanding biology at the molecular level have been created as a result of the complete sequencing and extensive annotation of different genomes. The scientific community is just starting to uncover the agents and mechanisms taking part in the molecular biology of different organisms as we identify their genes and gene products and the corresponding biological and molecular roles of these. The .
