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Pathogenesis Opportunistic infection, most often in an immunocompromised host, particularly with HIV disease Clinical manifestation Multiple pustules; infiltrated papules and plaques; subcutaneous nodules; non-healing cutaneous ulcers; distribution mainly on the extremities | A Abrikossof s tumor Granular cell tumor Abscess Definition Accumulation of pus in tissue usually caused by a bacterial infection Furuncle References Lowy FD 1998 Staphylococcus aureus infections. New England Journal of Medicine 339 520-532 I--------------------------------- Academy rash Erythema infectiosum I--------------------------------- Acanthamebiasis Synonym s None Definition Cutaneous and or systemic infection caused by one of several species of acanthamoeba Pathogenesis Opportunistic infection most often in an immunocompromised host particularly with HIV disease Clinical manifestation Multiple pustules infiltrated papules and plaques subcutaneous nodules non-healing cutaneous ulcers distribution mainly on the extremities Differential diagnosis Furunculosis disseminated varicella zoster infection deep fungal infection bacillary angiomatosis myctobacterial infection pyoderma gangrenosum Therapy Multidrug regimen for systemic disease pentamidine flucytosine fluconazole sulfadiazine References Murakawa GJ McCalmont T Altman J Telang GH Hoffman MD Kantor GR Berger TG 1995 Disseminated acanthamebiasis in patients with AIDS. A report of five cases and a review of the literature. Archives of Dermatology 131 11 0291-1296 2 Acanthoma fissuratum I--------------------------------------- Acanthoma fissuratum Synonym s Granuloma fissuratum spectacle frame granuloma acanthoma fissuratum cutis Definition Keratotic papule or nodule which develops at the site of chronic irritation such as under eye glasses or in the oral cavity Pathogenesis Chronic contact irritation includes other factors such as local anatomic changes seborrheic dermatitis and hyperhidrosis Clinical manifestation Oral cavity solitary smooth-surfaced papule at the juncture of the lip and gum Face or post-auricular fold pink papule with a longitudinal central fissure Differential diagnosis Oral cavity squamous cell carcinoma. Skin basal cell carcinoma foreign body granuloma chondrodermatitis nodularis .