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Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Human immunodeficiency virus and human papilloma virus - why HPV-induced lesions do not spontaneously resolve and why therapeutic vaccination can be successful | Journal of Translational Medicine BioMed Central Open Access Review Human immunodeficiency virus and human papilloma virus - why HPV-induced lesions do not spontaneously resolve and why therapeutic vaccination can be successful Sjoerd H van der Burg 1 2 and Joel M Palefsky1 2 Address Department of Clinical Oncology Leiden University Medical Center Leiden The Netherlands and 2Department of Medicine University of California San Francisco San Francisco CA USA Email Sjoerd H van der Burg - shvdburg@lumc.nl Joel M Palefsky-palefskyj@gcrc.ucsf.edu Corresponding author Published 18 December 2009 Received 5 November 2009 Journal of Translational Medicine 2009 7 108 doi 10.1 186 1479-5876-7-108 Accepted 18 December 2009 This article is available from http www.translational-medicine.cOm content 7 1 108 2009 Burg and Palefsky licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract HIV and HPV can both cause chronic infections and are acquired during sexual contact. HIV infection results in a progressive loss of CD4 T cells that is associated with an increased prevalence of HPV infections type-specific persistence and an increase in HPV-associated malignancies. On the one hand this illustrates the important role of HPV-specific CD4 helper T-cell immunity on the other it shows the Achilles heel of the HPV-specific immune response. The use of highly active antiretroviral therapy HAART results in a rapid reduction of HIV and a reconstitution of systemic CD4 T-cell levels. The use of HAART thus has the potential to raise immunity to HPV but to the surprise of many the incidence of HPV-induced diseases has increased rather than declined since the introduction of HAART. Here the knowledge on how HPV-induced diseases develop in the face of a
