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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: How complete are current yeast and human protein-interaction networks? | Opinion How complete are current yeast and human protein-interaction networks G Traver Hart Arun K Ramani and Edward M Marcotte Addresses Center for Systems and Synthetic Biology Institute for Cellular and Molecular Biology University of Texas at Austin 2500 Speedway Austin TX 78712 USA. Current address The Wellcome Trust Sanger Institute Wellcome Trust Genome Campus Hinxton Cambridge Cb1o 1SA UK. Correspondence Edward M Marcotte. Email marcotte@icmb.utexas.edu Published I December 2006 Genome Biology 2006 7 I20 doi I0.II86 gb-2006-7-II-I20 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2005 7 II I20 2006 BioMed Central Ltd Abstract We estimate the full yeast protein-protein interaction network to contain 37 800-75 500 interactions and the human network 154 000-369 000 but owing to a high false-positive rate current maps are roughly only 50 and 10 complete respectively. Paradoxically releasing raw unfiltered assay data might help separate true from false interactions. Networks are invaluable models for bettering our understanding of biological systems. Whether its constituent parts are molecules cells or living organisms a network provides an organizing framework amenable to modeling the complex events that emerge from interactions among the parts. In functional genomics concerted efforts over the past decade or so have produced rudimentary maps of the networks of genes proteins and metabolites controlling cells and with these maps have offered the promise of predictive rather than just descriptive models of molecular biology. Already the network of physical interactions the interactome among yeast proteins generated through a succession of experimental and algorithmic reconstructions has proved its usefulness for discovering protein function 1 2 predicting cellular behavior 3 4 and the analysis of complex gene regulation 5-7 . Similar efforts for protein-interaction networks for Caenorhabditis elegans .
