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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Independent centromere formation in a capricious, gene-free domain of. | Research Open Access Independent centromere formation in a capricious gene-free domain of chromosome I3q2l in Old World monkeys and pigs Maria Francesca Cardone Alicia Alonso Michele Pazienza Mario Ventura Gabriella Montemurro Lucia Carbone Pieter J de Jong Roscoe Stanyon Pietro D Addabbo Nicoletta Archidiacono Xinwei She Evan E Eichler Peter E Warburton and Mariano Rocchi Addresses Department of Genetics and Microbiology University of Bari Bari Italy. Department of Human Genetics Mount Sinai School of Medicine New York New York 10029 USA. Children s Hospital Oakland Research Institute Oakland California 94609 USA. Department of Animal Biology and Genetics Leo Pardi University of Florence Florence Italy. Howard Hughes Medical Institute Department of Genome Sciences University of Washington School of Medicine Seattle Washington 98195 USA. Correspondence Mariano Rocchi. Email rocchi@biologia.uniba.it Published 13 October 2006 Genome Biology 2006 7 R91 doi 10.1 186 gb-2006-7-10-r91 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2006 7 10 R91 Received 3 May 2006 Revised 31 July 2006 Accepted 13 October 2006 2006 Cardone et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Evolutionary centromere repositioning and human analphoid neocentromeres occurring in clinical cases are very likely two stages of the same phenomenon whose properties still remain substantially obscure. Chromosome 13 is the chromosome with the highest number of neocentromeres. We reconstructed the mammalian evolutionary history of this chromosome and characterized two human neocentromeres at 13q21 in search of information that could improve our understanding of the .
