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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: The Homer family proteins. | Protein family review The Homer family proteins Yoko Shiraishi-Yamaguchi 4 and Teiichi Furuichi Addresses Laboratory for Molecular Neurobiology RIKEN Brain Science Institute 2-1 Hirosawa Wako Saitama 351-0198 Japan. Department of Anatomy and Neurobiology Nagasaki University School of Medicine 1-12-4 Sakamoto Nagasaki Nagasaki 852-8523 Japan. Correspondence Teiichi Furuichi. Email tfuruichi@brain.riken.jp Published 21 February 2007 Genome Biology 2007 8 206 doi l0.ll86 gb-2007-8-2-206 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2007 8 2 206 2007 BioMed Central Ltd Summary The Homer family of adaptor proteins consists of three members in mammals and homologs are also known in other animals but not elsewhere. They are predominantly localized at the post-synaptic density in mammalian neurons and act as adaptor proteins for many postsynaptic density proteins. As a result of alternative splicing each member has several variants which are classified primarily into the long and short forms. The long Homer forms are constitutively expressed and consist of two major domains the amino-terminal target-binding domain which includes an Enabled vasodilator-stimulated phosphoprotein Ena VASP homology 1 EVH1 domain and the carboxy-terminal self-assembly domain containing a coiled-coil structure and leucine zipper motif. Multimers of long Homer proteins coupled through their carboxy-terminal domains are thought to form protein clusters with other postsynaptic density proteins which are bound through the amino-terminal domains. Such Homer-mediated clustering probably regulates or facilitates signal transduction or cross-talk between target proteins. The short Homer forms lack the carboxyterminal domain they are expressed in an activity-dependent manner as immediate-early gene products possibly disrupting Homer clusters by competitive binding to target proteins. Homer proteins are also involved in diverse non-neural .
