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Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: Imaging with isotopes: high resolution and quantitation. | J. Biol. Journal of Biology BioMed Central Research news Imaging with isotopes high resolution and quantitation Jonathan B Weitzman Published 5 October 2006 Journal of Biology 2006 5 17 The electronic version of this article is the complete one and can be found online at http jbiol.com content 5 6 17 2006 BioMed Central Ltd Mass spectrometry technology provides a clear image of the future of quantitative microscopy By the help of Microscopes there is nothing so small as to escape our inquiry hence there is a new visible World discovered to the understanding. Thus wrote Robert Hooke in his pioneering work Micrographia 1 published by the Royal Society in 1664. In this revolutionary book Hooke described with excitement his discoveries using a simple light microscope coining the word cell to define the microscopic structures he saw in cork and plant samples. In this issue of Journal of Biology 2 Claude Lechene and colleagues describe a 21st century microscopy technology Figure 1 that also reveals images we have never seen before. Hooke was fascinated by the new vision of the world and the planets afforded by the lenses of the early light microscopes and telescopes of the 17th century. Ever since these discoveries researchers have been gazing at the microscopic world and developing better and better instruments to do so. Over the centuries the demanding needs of biologists have fuelled countless improvements in imaging technologies. For example electron microscopy has become a standard instrument for high-resolution imaging in the nanometer range in biology and scanning probe microscopy techniques provide three-dimensional images of atomic surfaces. Quantitative imaging with mass spectrometry Lechene of Harvard Medical School and Brigham and Women s hospital in Background Mass spectrometry separates ions of different mass charge ratios in order to analyze the composition of a sample. Isobars are nuclides nuclei of atoms or atomic clusters of the same apparent atomic .
