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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: The cnidarian-bilaterian ancestor possessed at least 56 homeoboxes: evidence from the starlet sea anemone, Nematostella vectensis. | Research Open Access The cnidarian-bilaterian ancestor possessed at least 56 homeoboxes evidence from the starlet sea anemone Nematostella vectensis Joseph F Ryan Patrick M Burton Maureen E Mazza Grace K Kwong James C Mullikin and John R Finnerty Addresses Bioinformatics Program Boston University Cummington Street Boston MA 02215 USA. National Human Genome Research Institute Fishers Lane Bethesda MD 20892 USA. Department of Biology Boston University Cummington Street Boston MA 02215 USA. Correspondence John R Finnerty. Email jrf3@bu.edu Published 24 July 2006 Genome Biology 2006 7 R64 doi 10.1 186 gb-2006-7-7-r64 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2006 7 7 R64 Received 24 November 2005 Revised 18 April 2006 Accepted 24 July 2006 2006 Ryan et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Homeodomain transcription factors are key components in the developmental toolkits of animals. While this gene superclass predates the evolutionary split between animals plants and fungi many homeobox genes appear unique to animals. The origin of particular homeobox genes may therefore be associated with the evolution of particular animal traits. Here we report the first near-complete set of homeodomains from a basal diploblastic animal. Results Phylogenetic analyses were performed on 1 30 homeodomains from the sequenced genome of the sea anemone Nematostella vectensis along with 228 homeodomains from human and 97 homeodomains from Drosophila. The Nematostella homeodomains appear to be distributed among established homeodomain classes in the following fashion 72 ANTP class one HNF class four LIM class five POU class 33 PRD class five SINE .
