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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Genetic control of hippocampal neurogenesis | Minireview Genetic control of hippocampal neurogenesis Christine D Pozniak and Samuel J Pleasure Address Department of Neurology Programs in Neuroscience and Developmental Biology University of California San Francisco CA 94143 USA. Correspondence Samuel J Pleasure. Email sam.pleasure@ucsf.edu Published 30 March 2006 Genome Biology 2006 7 207 doi l0.ll86 gb-2006-7-3-207 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2006 7 3 207 2006 BioMed Central Ltd Abstract Adult neurogenesis in the hippocampus is under complex genetic control. A recent comparative study of two inbred mouse strains using quantitative trait locus analysis has revealed that cell survival is most highly correlated with neurogenesis and identified candidate genes for further investigation. Neurogenesis - the production of new neurons - is an ongoing process that persists in the adult brain of several species including humans. It has been most intensively studied in the mouse in two discrete brain regions the subventricular zone SVZ lining the lateral wall of the lateral ventricles and the subgranular zone SGZ of the dentate gyrus of the hippocampus 1 Figure 1 . These regions harbor relatively quiescent astrocyte-like stem cells which divide and give rise to multipotential rapidly dividing transit-amplifying cells that will eventually differentiate into neuroblasts. These later generate neuroblasts that are believed to have limited further mitotic potential 2 3 . Neuroblasts from the SVZ and SGZ migrate and eventually mature into functional neurons within the olfactory bulb and dentate gyrus respectively. Most recent evidence suggests that the stem cells in these regions can also give rise to astrocytes and oligodendrocytes of the glial lineage indicating that in vivo as in vitro these cells are multipotent 4 . A recent study by Kempermann et al. 5 in the Proceedings of the National Academy of Sciences of the USA sheds interesting new .
