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Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: Stage debut for the elusive Drosophila insulin-like growth factor binding proteins. | Journal of Biology BioMed Central Minireview Stage debut for the elusive Drosophila insulin-like growth factor binding protein Nazif Alic and Linda Partridge Address Institute of Healthy Ageing GEE University College London Gower Street London WC1E 6BT UK. Correspondence Linda Partridge. Email l.partridge@ucl.ac.uk Published 7 July 2008 Journal of Biology 2008 7 18 doi 10.1186 jbiol79 The electronic version of this article is the complete one and can be found online at http jbiol.com content 7 6 18 2008 BioMed Central Ltd Abstract Insulin-like growth factor IGF binding proteins provide a layer of complexity to the insulin IGF signaling system in mammals but only now in a recent study in Journal of Biology has one such protein been functionally characterized in Drosophila. The first insect protein with the capacity to bind mammalian insulin and insulin-like peptides had a serendipitous discovery eight years ago. A 27 kDa protein from the fall armyworm Spodoptera frugiperda was uncovered as an insulin-binding activity in insect-cell-conditioned media during attempts to purify fragments of the insulin receptor from Sf9 cells 1 . The protein was purified and identified allowing subsequent identification of its single Drosophila homolog Imp-L2 1 . In a recent study in Journal of Biology Honegger and coworkers 2 present the first and long-awaited in vivo functional characterization of this insect insulin insulin-like growth factor IGF binding protein. Insulin IGF signaling and IGF binding proteins The insulin IGF signaling IIS pathway is an evolutionarily conserved neuroendocrine signaling pathway that regulates a plethora of metazoan functions and traits both during development and in the adult. In model animals ranging from the nematode worm and the fruit fly to the mouse IIS affects growth and development metabolic energy homeostasis stress resistance reproduction and lifespan 3-5 . The cellular IIS cascade is initiated by the extracellular binding of an insulin .
