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Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: The Drosophila Forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling. | J. Biol. Journal of Biology BioMed Central Research article Open Access The Drosophila Forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling Martin A Junger Felix Rintelen Hugo Stocker Jonathan D Wasserman Mátyás Végh Thomas Radimerski Michael E Greenberg and Ernst Hafen Addresses Zoologisches Institut Universitat Zurich Winterthurerstr. 190 CH-8057 Zurich Switzerland. tCurrent address Serono Pharmaceutical Research Institute Serono International S.A. 14 Chemin des Aulx CH-1228 Plan-les-Ouates Geneva Switzerland. Division of Neuroscience Children s Hospital and Department of Neurobiology Harvard Medical School 300 Longwood Ave Boston MA 02115 USA. Current address Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology Cambridge MA 02139 USA. lInstitut fur Molekularbiologie Universitat Zurich Winterthurerstr. 190 CH-8057 Zurich Switzerland. Current address The Genetics Company Inc. Wagistr. 27 CH-8952 Schlieren Switzerland. Friedrich-Miescher-Institut Novartis Research Foundation Maulbeerstr. 66 CH-4058 Basel Switzerland. Correspondence Ernst Hafen. E-mail hafen@zool.unizh.ch Published 7 August 2003 Received 28 March 2003 Revised 2 July 2003 Journal of Biology 2003 2 20 J IS Accepted 9 July 2003 The electronic version of this article is the complete one and can be found online at http jbiol.com content 2Z3 20 2003 Junger et al. licensee BioMed Central Ltd. This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract Background Forkhead transcription factors belonging to the FOXO subfamily are negatively regulated by protein kinase B PKB in response to signaling by insulin and insulinlike growth factor in Caenorhabditis elegans and mammals. In Drosophila the insulin-signaling pathway regulates the size of cells organs and the .
