Đang chuẩn bị nút TẢI XUỐNG, xin hãy chờ
Tải xuống
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Close encounters between active genes in the nucleus. | Minireview Close encounters between active genes in the nucleus Chien-Hui Chuang and Andrew S Belmont Address Department of Cell and Developmental Biology University of Illinois at Urbana-Champaign 601 South Goodwin Avenue Urbana IL 61801 uSa. Correspondence Andrew S Belmont. E-mail asbel@uiuc.edu Published 19 October 2005 Genome Biology 2005 6 237 doi l0.ll86 gb-2005-6-ll-237 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2005 6 ll 237 2005 BioMed Central Ltd Abstract A recent paper demonstrates that coregulated genes on different chromosomes show surprisingly high frequencies of colocalization within the nucleus this complements similar results found previously for genes localized tens of megabases apart on a single chromosome. Colocalization could be related to the earlier observation of active genes associating with foci where RNA polymerase II is concentrated. Nuclear compartmentalization and its study using the 3C method The nucleus is still not infrequently perceived as a microscopic test tube in which activities such as transcription replication and recombination are performed on a template of randomly coiled chromatin bathed in a homogeneous nucleoplasm containing soluble enzymes and cofactors. Yet in recent years there has been a growing appreciation that the nucleus is in fact highly organized. In interphase chromosomes DNA is compacted by varying amounts from hundreds to thousands of times more compact than simple B-form DNA 1 and the chromosomes form distinct largely non-overlapping territories 2 that are non-randomly arranged within the nucleus. As well as chromosome territories a plethora of other nuclear compartments and bodies have been identified and many of the cofactors and enzymes mediating the processing of DNA and RNA are enriched in particular compartments or bodies 3 . The functional significance of this considerable nuclear compartmentalization remains unclear given that most .
