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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Systems biology approaches in cell signaling research. | Minireview Systems biology approaches in cell signaling research Raymond E Chen and Jeremy Thorner Address Division of Biochemistry and Molecular Biology Department of Molecular and Cell Biology University of California Berkeley CA 94720-3202 USA. Correspondence Jeremy Thorner. E-mail jthorner@berkeley.edu Published 29 September 2005 Genome Biology 2005 6 235 doi l0.ll86 gb-2005-6-l0-235 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2005 6 10 235 2005 BioMed Central Ltd Abstract The use of methods for global and quantitative analysis of cells is providing new systems-level insights into signal transduction processes. Recent studies reveal important information about the rates of signal transmission and propagation help establish some general regulatory characteristics of multi-tiered signaling cascades and illuminate the combinatorial nature of signaling specificity in cell differentiation. The most useful road maps are those that provide an overview of the major highways as well as displaying street-by-street detail for specific locations to reveal the connections at points of interest. In the same sense a major goal of current research is to collect information and devise tools to help us understand biological phenomena at multiple levels of abstraction. Traditional biochemistry and molecular biology focus on the properties of individual molecules including for proteins and enzymes their immediate subparts domains their substrates and ligands and the company they keep interacting partners and complexes . This approach has been remarkably successful at elucidating the structures and functions of many cellular constituents and will continue to be so for years to come. In contrast our understanding of biological processes at larger scales of resolution such as entire intracellular signal transduction networks is much less developed. Over the past few years powerful methodological advances have enabled .
