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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: The lords of the genomes. | Meeting report The lords of the genomes Mark Stapleton Address Berkeley Drosophila Genome Project Lawrence Berkeley National Laboratory 1 Cyclotron Road Berkeley CA 94720 USA. E-mail staple@fruitfly.org Published 28 September 2004 Genome Biology 2004 5 349 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2004 5 10 349 2004 BioMed Central Ltd A report on The Biology of Genomes meeting Cold Spring Harbor USA 12-16 May 2004. At this year s annual Cold Spring Harbor Laboratory genome meeting entitled The Biology of Genomes the focus was progress in the emerging field of high-throughput functional biology. All the major players in the genomics field were in attendance and the cover of the abstract book depicted them as the lords of the DNA ring. Genomics is clearly moving from its initial structural phase sequencing into a functional phase. Three broad research directions showed particular promise and some of the significant progress is summarized here. Regulatory networks Large-scale genome projects have contributed greatly to our understanding of the structure of the genome and continue to make important contributions to biology. The resources generated by these projects have spawned innovative atempts towards understanding cellular and molecular processes. In particular a comprehensive understanding of transcriptional regulatory circuits is now being pursued in many organisms. High-throughput promoter bashing can be accomplished using a combination of comparative sequence analysis and computational algorithms to identify and characterize regulatory sequences. Using architectural features that are evolutionarily conserved between different Drosophila species work presented by Mike Eisen Lawrence Berkeley National Laboratory Berkeley USA expanded on the previous identification of local clusters of known transcription-factor binding sites in Drosophila melanogaster. He examined differences between bindingsite .
