Đang chuẩn bị nút TẢI XUỐNG, xin hãy chờ
Tải xuống
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: A non-random walk through the genome. | Review A non-random walk through the genome Brian Oliver and Tom Mistelit Addresses National Institute of Diabetes and Digestive and Kidney Diseases National Institutes of Health Department of Health and Human Services Bethesda MD 20892 USA. tNational Cancer Institute National Institutes of Health Department of Health and Human Services Bethesda MD 20892 USA. Correspondence Brian Oliver. E-mail oliver@helix.nih.gov. Tom Misteli. E-mail mistelit@mail.nih.gov Published 31 March 2005 Genome Biology 2005 6 214 doi I0.II86 gb-2005-6-4-2l4 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2005 6 4 2I4 2005 BioMed Central Ltd Abstract Recent publications on a wide range of eukaryotes indicate that genes showing particular expression patterns are not randomly distributed in the genome but are clustered into contiguous regions that we call neighborhoods. It seems probable that this organization is related to chromatin and the structure of the nucleus. Consideration of gene regulation as an interaction between the basal transcription machinery regulators and a segment of naked DNA containing a gene has been an extremely successful model for understanding how genetic information is read 1 . It is impossible to separate this model from the great success of modern molecular genetics. Naked DNA does not exist in nature however. Packing DNA into the nucleus segregating it during cell division and making sure that it is readily available when needed for transcription is an enormously complex task for the cell and needs extensive interactions of proteins with DNA. Structural considerations have dominated our views of nuclear architecture but have not greatly influenced our concepts of transcription other than by the broad assumption that such structure can hinder transcription. As with a building however the structure of the nucleus has a significant albeit possibly subtle influence on the work performed within it. Recent .