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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Tumor microenvironments, the immune system and cancer survival. | Minireview Tumor microenvironments the immune system and cancer survival Robert L Strausberg Address J. Craig Venter Institute 9 704 Medical Center Drive Rockville MD 20850 USA. E-mail RLS@venterinstitute.org Published I March 2005 Genome Biology 2005 6 211 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2005 6 3 211 2005 BioMed Central Ltd Abstract The study of cancer immunology has recently been reinvigorated by the application of new research tools and technologies as well as by refined bioinformatics methods for interpretation of complex datasets. Recent microarray analyses of lymphomas suggest that the prognosis of cancer patients is related to an interplay between cancer cells and their microenvironment including the immune response. That the immune system plays an important role in the regulation and outcome of cancer has been an intriguing concept for almost a century. As discussed by Dunn et al. 1 2 although many observations supported the notion that the ability of cancer to escape the tumor-controlling features of the immune system can be considered a hallmark of cancer for many years the scientific evidence was conflicting and consensus did not emerge. More recently however advances in approaches that perturb specific gene functions in well-defined mouse models of cancer have convincingly demonstrated the importance of the interface between cancer and the immune system 2 . Together with a large body of evidence from human cancers these advances have generated renewed interest in understanding the role of the host inflammatory response in cancer and in using that knowledge towards the development of new approaches to cancer immunotherapy and vaccination 3-10 . The recently reported results of two groups 11 12 give new insights into the factors that affect survival of patients with lymphomas including the importance of the immune system. Initially the study of cancer immunobiology was framed .
