Đang chuẩn bị nút TẢI XUỐNG, xin hãy chờ
Tải xuống
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Wound healing and inflammation genes revealed by array analysis of 'macrophageless' PU.1 null mice. | Research Open Access Wound healing and inflammation genes revealed by array analysis of macrophageless PU.I null mice Lisa Cooper Claire Johnson Frank Burslem and Paul Martin Addresses Department of Anatomy and Developmental Biology University College London London WC1E 6BT UK. Pfizer Global Research and Development Sandwich Kent CT13 9NJ UK. Departments of Physiology and Biochemistry University of Bristol Bristol BS8 1TD UK. Current Address Molecular Neuroscience Group School of Medicine University of Birmingham Birmingham B15 2TH UK. Correspondence Paul Martin. E-mail paul.martin@bristol.ac.uk Published 23 December 2004 Genome Biology 2004 6 R5 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2004 6 1 R5 Received 2 September 2004 Revised 29 October 2004 Accepted 24 November 2004 2004 Cooper et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Wound healing is a complex process requiring the collaborative efforts of different tissues and cell lineages and involving the coordinated interplay of several phases of proliferation migration matrix synthesis and contraction. Tissue damage also triggers a robust influx of inflammatory leukocytes to the wound site that play key roles in clearing the wound of invading microbes but also release signals that may be detrimental to repair and lead to fibrosis. Results To better define key cellular events pivotal for tissue repair yet independent of inflammation we have used a microarray approach to determine a portfolio of over 1 000 genes expressed across the repair response in a wild-type neonatal mouse versus its PU.I null sib. The PU.I null mouse is genetically incapable of raising the standard .
