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Membrane rafts are microdomains involved in a number of biologically important processes, including immunoreceptor signalling. Among the functionally important protein components of these microdomains are transmembrane adaptor proteins, containing in their intracellular domains tyrosine residues that can be phosphorylated and bind other cytoplasmic signalling proteins. | ỊFEBS Journal THE SIR HANS KREBS LECTURE LAT - an important raft-associated transmembrane adaptor protein Delivered on 6 July 2009 at the 34th FEBS Congress in Prague Czech Republic Václav Horejsi Pavel Otahal and Tomas Brdicka Institute of Molecular Genetics Academy of Sciences of the Czech Republic Prague Czech Republic Keywords immunoreceptor signalling LAT raft transmembrane adaptor protein tyrosine phosphorylation Correspondence V. Horejsi Institute of Molecular Genetics AS CR Vídeiăská 1083 142 20 Prague 4 Czech Republic Fax 420 244472282 Tel 420 241729908 E-mail horejsi@biomed.cas.cz Received 8 July 2010 revised 12 August 2010 accepted 24 August 2010 Membrane rafts are microdomains involved in a number of biologically important processes including immunoreceptor signalling. Among the functionally important protein components of these microdomains are transmembrane adaptor proteins containing in their intracellular domains tyrosine residues that can be phosphorylated and bind other cytoplasmic signalling proteins. The most important leukocyte transmembrane adaptor protein is LAT linker for activation of T cells which is critically involved in T cell receptor signalling but also plays important roles in signal initiation by several other immunologically important receptors. Here we review recent progress in the elucidation of several aspects of this protein e.g. the controversy concerning the importance of LAT being present in membrane rafts the involvement in signalling through a number of receptors other than the T cell receptor and the puzzling phenotype of some LAT mutants. doi 10.1111 j.1742-4658.2010.07831.x Introduction A number of immunologically important receptors e.g. T cell and B cell antigen receptors TCR BCR Fc-receptors natural killer NK myeloid cell activating receptors collagen receptor on platelets some cytokine receptors employ common functional principles for signal transduction. These multichain receptor complexes consist of a .
