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Follistatin-related protein (FRP)⁄follistatin-like 1 (FSTL1) is a member of the follistatin protein family, all of which share a characteristic structure unit found in follistatin, called the FS domain. Developmental studies have suggested that FRP regulates organ tissue formation in embryos. Immunological studies showed that FRP modifies joint inflammation in arthritic disease, and modu-lates allograft tolerance. | DIP2 disco-interacting protein 2 homolog A Drosophila is a candidate receptor for follistatin-related proteinfollistatin-like 1 - analysis of their binding with TGF-p superfamily proteins t IncQii Tqn 1 3 1 ki I 1 I I mlzomi2 I m IÍ- I I fÌ7alzí3 ziclii i x i 11711 Im2 3 1 A-Ponn Tnnn1 Tnlziim IVIasaU laUaka IXUsakU iviutakallll Olioiulli Ozaki TUoHIlaka Imuta Alaulcliy lolly lakuu A i i II a 11 04 Tn c 11 I m Izi Qsmrslzi1 Tiilziifi 11711 kmA Q n a 17111 rToicz I ilzm l aiA a tia a2 Talzoii Fl I i ĨĨ2 Toksc hi I Icii 2 WalallaUc lusiliukl OaWaki lakaiumi IxaWallallll Daisukc IKaWaUala lakaU FUJII lakasni Usui Yasufumi Masaki1 Yoshihiro Fukushima1 Zhe-Aiong Jin1 Hisanori Umehara1 and lsuneyo Mimori2 1 Division of Hematology and Immunology Department of InternalMedicine Kanazawa MedicalUniversity Ishikawa Japan 2 Department of Rheumatology and ClinicalImmunology Kyoto University Graduate Schoolof Medicine Japan 3 Division of Rheumatology and Allergy Department of InternalMedicine St Marianna University Schoolof Medicine Kanagawa Japan 4 Department of Biochemistry and Molecular Vascular Biology Kanazawa University Graduate Schoolof MedicalScience Ishikawa Japan Keywords disco DMAP1 FLRG occ1 SPARC Correspondence M. Tanaka Division of Hematology and Immunology Department of Internal Medicine Kanazawa MedicalUniversity 1-1 Daigaku Uchinada Kahoku-gun Ishikawa 920-0293 Japan Fax 81 76 286 9290 Tel 81 76 286 2211 ext. 3532 E-mail masatana@kanazawa-med.ac.jp tanakama@mail.nih.gov Website http www.kanazawa-med.ac.jp Masao Tanaka and Kosaku Murakami contributed equally to this work Received 19 May 2010 revised 11 August 2010 accepted 17 August 2010 doi 10.1111 j.1742-4658.2010.07816.x Follistatin-related protein FRP follistatin-like 1 FSTL1 is a member of the follistatin protein family all of which share a characteristic structure unit found in follistatin called the FS domain. Developmental studies have suggested that FRP regulates organ tissue formation in embryos. .
