Đang chuẩn bị nút TẢI XUỐNG, xin hãy chờ
Tải xuống
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Systematic analysis of alternative first exons in plant genomes | BMC Plant Biology BioMed Central Research article Open Access Systematic analysis of alternative first exons in plant genomes Wei-Hua Chen11 4 Guanting Lv11 2 Congying Lv3 Changqing Zeng1 and Songnian Hu 1 Address 1Key Laboratory of Genome Science and Information Beijing Institute of Genomics Chinese Academy of Sciences Beijing China 2Graduate School of Chinese Academy of Sciences Beijing China 3Nanyang Institute of Technology Henan China and 4Bioinformatics Heinrich-Heine-University Duesseldorf Germany Email Wei-Hua Chen - chenwh550@gmail.com Guanting Lv - lvgt@genomics.org.cn Congying Lv - Alin0378@SOHU.com Changqing Zeng - czeng@genomics.org.cn Songnian Hu - husn@genomics.org.cn Corresponding author fEqual contributors Published 17 October 2007 Received 17 February 2007 BMC Plant Biology 2007 7 55 doi l0.ll86 l47l-2229-7-55 Accepted I7 October 2007 This article is available from http www.biomedcentral.com l47l-2229 7 55 2007 Chen et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Alternative splicing AS contributes significantly to protein diversity by selectively using different combinations of exons of the same gene under certain circumstances. One particular type of AS is the use of alternative first exons AFEs which can have consequences far beyond the fine-tuning of protein functions. For example AFEs may change the N-termini of proteins and thereby direct them to different cellular compartments. When alternative first exons are distant they are usually associated with alternative promoters thereby conferring an extra level of gene expression regulation. However only few studies have examined the patterns of AFEs and these analyses were mainly focused on mammalian genomes. Recent studies have
