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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Gene expression profiling of human prostate cancer stem cells reveals a pro-inflammatory phenotype and the importance of extracellular matrix interactions. | Open Access Gene expression profiling of human prostate cancer stem cells reveals a pro-inflammatory phenotype and the importance of extracellular matrix interactions Richard Birnie Steven D Bryce Claire Roome Vincent Dussupt Alastair Droop Shona H Lang Paul A Berry Catherine F Hyde John L Lewis Michael J Stowed Norman J Maitland and Anne T Collins Addresses Pro-Cure Therapeutics Ltd The Biocentre Innovation Way York Science Park Heslington York YO1O 5NY UK. WCR Cancer Research Unit Department of Biology University of York York YO1O 5YW UK. Hull York Medical School University of York Heslington York YO1O 5DD UK. York Centre for Complex Systems Analysis Department of Biology University of York York YO1O 5YW UK. Department of Urology York Hospital Wigginton Road York YO31 8HE UK. Correspondence Anne T Collins. Email ac43@york.ac.uk Published 20 May 2008 Genome Biology 2008 9 R83 doi 10.1 186 gb-2008-9-5-r83 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2008 9 5 R83 Received 20 December 2007 Revised 5 March 2008 Accepted 20 May 2008 2008 Birnie et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The tumor-initiating capacity of many cancers is considered to reside in a small subpopulation of cells cancer stem cells . We have previously shown that rare prostate epithelial cells with a CD133 a2P1hi phenotype have the properties of prostate cancer stem cells. We have compared gene expression in these cells relative to their normal and differentiated CD133- a2P ow counterparts resulting in an informative cancer stem cell gene-expression signature. Results Cell cultures were generated from specimens of human prostate cancers n 12 and non-malignant
