Đang chuẩn bị nút TẢI XUỐNG, xin hãy chờ
Tải xuống
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài:A truly titanic figure in science. | Comment A truly titanic figure in science Gregory A Petsko Address Rosenstiel Basic Medical Sciences Research Center Brandeis University Waltham MA 02454-9110 USA. Email petsko@brandeis.edu Published 31 July 2007 Genome Biology 2007 8 108 doi 10.1186 gb-2007-8-7-108 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2007 8 7 108 2007 BioMed Central Ltd I almost had this month s column finished when I got the news then I knew I had to write a different one. The news was that Dan Koshland one of the truly titanic figures in American science in the past 50 years had died of a massive stroke at age 87 on Monday 23 July. Dan always said that his ambition was to die young as old as possible. He succeeded very few people of any age have had a younger heart or a more open mind. He went the way we should all go suddenly while still sharp and having fun. In fact he called his delightful autobiographical sketch How to get paid for having fun Koshland DE Annu Rev Biochem 1999 65 1-13 and few scientists have enjoyed themselves more. His scientific accomplishments were vast ranging from the development of fundamental concepts in enzymology to important advances in understanding sensory transduction through his work on bacterial chemotaxis. He managed to combine a gift for theorizing with a talent for clever but rigorous experiments - a feat that few have done so well. And throughout it all he gave the impression that he was just a kid playing with his favorite toy. He was my friend for over 30 years. I first met him when I was a graduate student in England and he was on sabbatical there. I knew who he was of course - he was already famous for his work on enzymes. In the late 1950s he did a series of experiments on the enzyme hexokinase that were incompatible with the rigid lock-and-key picture of how an enzyme works that had stood as dogma for half a century. To explain his results he formulated what he called the induced