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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài:Toxicogenomic analysis of Caenorhabditis elegans reveals novel genes and pathways involved in the resistance to cadmium toxicity. | Open Access Research Toxicogenomic analysis of Caenorhabditis elegans reveals novel genes and pathways involved in the resistance to cadmium toxicity Yuxia Cui Sandra J McBride Windy A Boyd Scott Alper and Jonathan H Freedman Addresses Nicholas School of the Environment and Earth Sciences Duke University Durham NC 27708 USA. Taboratory of Molecular Toxicology National Institute of Environmental Health Sciences NIH Research Triangle Park NC 27709 USA. Laboratory of Environmental Lung Disease National Heart Lung and Blood Institute Bethesda MD 20892 USA. Department of Medicine Duke University Medical Center Durham NC 27707 USA. Correspondence Jonathan H Freedman. Email freedma1@niehs.nih.gov Published 25 June 2007 Genome Biology 2007 8 R122 doi l0.ll86 gb-2007-8-6-rl 22 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2007 8 6 R122 Received 9 March 2007 Revised 22 May 2007 Accepted 25 June 2007 2007 Cui et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Exposure to cadmium is associated with a variety of human diseases. At low concentrations cadmium activates the transcription of stress-responsive genes which can prevent or repair the adverse effects caused by this metal. Results Using Caenorhabditis elegans 290 genes were identified that are differentially expressed 1.5-fold following a 4 or 24 hour exposure to cadmium. Several of these genes are known to be involved in metal detoxification including mtl-l mtl-2 cdr-l and ttm-l confirming the efficacy of the study. The majority however were not previously associated with metal-responsiveness and are novel. Gene Ontology analysis mapped these genes to cellular ion trafficking metabolic enzymes
