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Tham khảo luận văn - đề án 'báo cáo khoa học: " detection of hepatitis e virus in wild boars of rural and urban regions in germany and whole genome characterization of an endemic strain"', luận văn - báo cáo phục vụ nhu cầu học tập, nghiên cứu và làm việc hiệu quả | Virology Journal BioMed Central Research Detection of hepatitis E virus in wild boars of rural and urban regions in Germany and whole genome characterization of an endemic strain Anika Schielke1 Katja Sachs2 Michael Lierz3 Bernd Appel1 Andreas Jansen4 and Reimar Johne 1 Open Access Address Federal Institute for Risk Assessment Diedersdorfer Weg 1 12277 Berlin Germany 2State Office for Food Safety and Consumer Protection Thuringia Bad Langensalza Germany 3Free University of Berlin Faculty for Veterinary Medicine Germany and 4Robert Koch Institute Department for Infectious Disease Epidemiology Berlin Germany Email Anika Schielke - Anika.Schielke@bfr.bund.de Katja Sachs - Katja.Sachs@tllv.thueringen.de Michael Lierz - lierz.michael@vetmed.fu-berlin.de Bernd Appel - Bernd.Appel@bfr.bund.de Andreas Jansen - JansenA@rki.de Reimar Johne - Reimar.Johne@bfr.bund.de Corresponding author Published 14 May 2009 Received 16 February 2009 Virology Journal 2009 6 58 doi l0.ll86 l743-422X-6-58 Accepted I4 May 2009 This article is available from http www.virologyj.cOm content 6 1 58 2009 Schielke et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Hepatitis E is an increasingly diagnosed human disease in Central Europe. Besides domestic pigs in which hepatitis E virus HEV infection is highly prevalent wild boars have been identified as a possible source of human infection. In order to assess the distribution of HEV in the wild boar population of Germany we tested liver samples originating from different geographical regions for the presence of the HEV genome and compared the detected sequences to animal and human HEV strains. Results A total of 148 wild boar liver samples were tested using real-time RT-PCR resulting in
