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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Soluble triggering receptor on myeloid cells-1 is expressed in the course of non-infectious inflammation after traumatic lung contusion: a prospective cohort study. | Bingold et al. Critical Care 2011 15 R115 http ccforum.eom content 15 2 R115 KS CRITICAL CARE RESEARCH Open Access Soluble triggering receptor on myeloid cells-1 is expressed in the course of non-infectious inflammation after traumatic lung contusion a prospective cohort study 1 1 1 2 2 1 Tobias M Bingold Barbara Pullmann Sven Sartorius Emanuel V Geiger Ingo Marzi Kai Zacharowski Heimo Wissing3t and Bertram Scheller 1 Abstract Introduction The triggering receptor expressed on myeloid cells-1 TREM-1 is known to be expressed during bacterial infections. We investigated whether TREM-1 is also expressed in non-infectious inflammation following traumatic lung contusion. Methods In a study population of 45 adult patients with multiple trauma and lung contusion we obtained bronchoalveolar lavage BAL blind suctioning of 20 ml NaCl 0.9 via jet catheter and collected blood samples at two time points 16 hours and 40 hours after trauma. Post hoc patients were assigned to one of four groups radiologically classified according to the severity of lung contusion based on the initial chest tomography. Concentration of soluble TREM-1 sTREM-1 and bacterial growth were determined in the BAL. sTREM-1 IL-6 IL-10 lipopolysaccharide binding protein procalcitonin C-reactive protein and leukocyte count were assessed in blood samples. Pulmonary function was evaluated by the paO2 FiO2 ratio. Results Three patients were excluded due to positive bacterial growth in the initial BAL. In 42 patients the severity of lung contusion correlated with the levels of sTREM-1 16 hours and 40 hours after trauma. sTREM-1 levels were significantly P 0.01 elevated in patients with severe contusion 2 184 pg ml 620 to 4 000 pg ml in comparison with patients with mild 339 pg ml 135 to 731 pg ml or no 217 pg ml 97 to 701 pg ml contusion 40 hours following trauma. At both time points the paO2 FiO2 ratio correlated negatively with sTREM-1 levels Spearman correlation coefficient -0.446 P 0.01 . Conclusions sTREM-1 .
