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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Production and purification of immunologically active core protein p24 from HIV-1 fused to ricin toxin B subunit in E. coli | Virology Journal BioMed Central Open Access Production and purification of immunologically active core protein p24 from HIV-1 fused to ricin toxin B subunit in E. coli Alberto J Donayre-Torres1 Ernesto Esquivel-Soto2 María de Lourdes Gutiérrez-Xicoténcatl3 Fernando R Esquivel-Guadarrama2 and Miguel A Gómez-Lim 1 Address 1Centro de Investigation y de Estudios Avanzados CINVESTAV Unidad Irapuato Km 9.6 Libramiento Norte 36500 Carretera Irapuato-León Irapuato Guanajuato México 2Facultad de Medicina Universidad Autónoma del Estado de Morelos UAEM Cuernavaca-Morelos México and 3Centro de Investigaciones Sobre Enfermedades Infecciosas INSP SSA Cuernavaca-Morelos México Email Alberto J Donayre-Torres - albulb@rocketmail.com Ernesto Esquivel-Soto - eesquimx@yahoo.com.mx María de Lourdes Gutiérrez-Xicoténcatl - mlxico@correo.insp.mx Fernando R Esquivel-Guadarrama - fernando.esquivel@uaem.mx Miguel A Gomez- Lim - mgomez@ira.cinvestav.mx Corresponding author Published 6 February 2009 Received 15 December 2008 Accepted 6 February 2009 Virology journal 2009 6 17 doi l0.ll86 l743-422X-6-l7 This article is available from http www.virologyj.cOm content 6 l l7 2009 Donayre-Torres et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Gag protein from HIV-l is a polyprotein of 55 kDa which during viral maturation is cleaved to release matrix pl7 core p24 and nucleocapsid proteins. The p24 antigen contains epitopes that prime helper CD4 T-cells which have been demonstrated to be protective and it can elicit lymphocyte proliferation. Thus p24 is likely to be an integral part of any multicomponent HIV vaccine. The availability of an optimal adjuvant and carrier to enhance antiviral responses may accelerate the development of
