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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: High-resolution analysis of condition-specific regulatory modules in Saccharomyces cerevisiae. | Method Open Access High-resolution analysis of condition-specific regulatory modules in Saccharomyces cerevisiae Hun-Goo LeeH Hyo-Soo LeeH Sang-Hoon Jeon Tae-Hoon Chung Young-Sung Lim and Won-Ki Huh Addresses Department of Bioinformatics Dong-a Seetech Research Institute Seoul 135-010 Republic of Korea. School of Biological Sciences and Research Center for Functional Cellulomics Institute of Microbiology Seoul National University Seoul 151-747 Republic of Korea. Computational Biology Division TGEN N 5th St Phoenix Arizona 85004 USA. H These authors contributed equally to this work. Correspondence Won-Ki Huh. Email wkh@snu.ac.kr Published 3 January 2008 Genome Biology 2008 9 R2 doi 10.1186 gb-2008-9-1-r2 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2008 9 1 R2 Received 18 July 2007 Revised 15 October 2007 Accepted 3 January 2008 2008 Lee et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract We present an approach for identifying condition-specific regulatory modules by using separate units of gene expression profiles along with ChIP-chip and motif data from Saccharomyces cerevisiae. By investigating the unique and common features of the obtained condition-specific modules we detected several important properties of transcriptional network reorganization. Our approach reveals the functionally distinct coregulated submodules embedded in a coexpressed gene module and provides an effective method for identifying various condition-specific regulatory events at high resolution. Background Transcription regulation is a starting point for controlling a variety of biological processes such as cell cycle progression and adaptive responses to environmental .
