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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Quantification of global transcription patterns in prokaryotes using spotted microarrays. | Open Access Method Quantification of global transcription patterns in prokaryotes using spotted microarrays Ben Sidders Mike Withers Sharon L Kendall Joanna Bacon Simon J Waddell Jason Hinds Paul Golby Farahnaz Movahedzadeh Robert A Cox Rosangela Frita Annemieke MC ten Bokum Lorenz Wernisch and Neil G Stoker Addresses Department of Pathology and Infectious Diseases Royal Veterinary College Royal College Street London NW1 0TU UK. School of Crystallography Birkbeck College London WC1E 7HX UK. TB Research CEPR Health Protection Agency Porton Down Salisbury SP4 OJG UK. Medical Microbiology Division of Cellular and Molecular Medicine St George s University of London Cranmer Terrace Tooting London SW17 ORE UK. Veterinary Laboratories Agency Woodham Lane New Haw Addlestone Surrey KT15 3NB UK. Institute for Tuberculosis Research College of Pharmacy University of Illinois at Chicago Chicago Illinois 60612-7231 USA. Division of Mycobacterial Research National Institute for Medical Research The Ridgeway Mill Hill London NW7 1AA UK. Department of Infectious and Tropical Diseases London School of Hygiene and Tropical Medicine London WC1E 7HT UK. Correspondence Neil G Stoker. Email nstoker@rvc.ac.uk Published 13 December 2007 Genome Biology 2007 8 R265 doi 10.1186 gb-2007-8- l2-r265 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2007 8 12 R265 Received 15 August 2007 Revised 1 November 2007 Accepted 1 3 December 2007 2007 Sidders et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract We describe an analysis applicable to any spotted microarray dataset produced using genomic DNA as a reference that quantifies prokaryotic levels of mRNA on a genome-wide scale. Applying