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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: The ins and outs of translation. | Meeting report The ins and outs of translation Jennifer L Clancy Marco Nousch Marina Rodnina and Thomas Preiss Addresses Molecular Genetics Program Victor Chang Cardiac Research Institute VCCRI Darlinghurst Sydney NSW 2010 Australia. fSt Vincent s Clinical School and School of Biotechnology and Biomolecular Sciences University of New South Wales Sydney NSW 2052 Australia. Institute of Physical Biochemistry University of Witten Herdecke Stockumer Strasse 10 58448 Witten Germany. Correspondence Thomas Preiss. Email t.preiss@victorchang.edu.au Published 7 December 2007 Genome Biology 2007 8 321 doi l0.ll86 gb-2007-8-l2-32l The electronic version of this article is the complete one and can be found online at http genomebiology.com 2007 8 l2 32l 2007 BioMed Central Ltd A report on the 2nd EMBO Conference on Protein Synthesis and Translational Control Heidelberg Germany 12-16 September 2007. The recent EMBO conference on protein synthesis and translational control held at the European Laboratory of Molecular Biology EMBL in Heidelberg provided an update on developments in a field that has become a major focus of gene-expression research. A packed audience thoroughly enjoyed contributions on ribosome structure and molecular details of the initiation elongation and termination steps of translation. Many examples of translational control were presented showcasing its biological significance and the depth of insight into its mechanisms that is now achievable. The ribosome and mechanisms of translation On the structural side two current challenges are to obtain structures of ribosomes complexed with their ligands and structures at higher resolution. Maria Selmer Uppsala University Uppsala Sweden presented a crystal structure of the 70S ribosome from Thermus thermophilus in complex with mRNA and three tRNAs at 2.8 Â resolution. Christian Spahn Charité Medical University Berlin Germany reported a cryo-electron microscopy reconstruction of ribosomes from Escherichia coli stalled
