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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Do Alu repeats drive the evolution of the primate transcriptome? | Open Access Research Do Alu repeats drive the evolution of the primate transcriptome Araxi O Urrutia Leandro Balladares Ocanan and Laurence D Hurst Addresses Department of Biology and Biochemistry University of Bath Bath BA4 7AY UK. Computer Research Center of the IPN Mexico City Mexico 07738. Department of Computer Engineering at University of California Santa Cruz Santa Cruz California 95064 USA. Correspondence Laurence D Hurst. Email l.d.hurst@bath.ac.uk Published I February 2008 Genome Biology 2008 9 R25 doi I0.I I86 gb-2008-9-2-r25 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2008 9 2 R25 Received 3 October 2007 Revised 2 January 2008 Accepted I February 2008 2008 Urrutia et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Of all repetitive elements in the human genome Alus are unusual in being enriched near to genes that are expressed across a broad range of tissues. This has led to the proposal that Alus might be modifying the expression breadth of neighboring genes possibly by providing CpG islands modifying transcription factor binding or altering chromatin structure. Here we consider whether Alus have increased expression breadth of genes in their vicinity. Results Contrary to the modification hypothesis we find that those genes that have always had broad expression are richest in Alus whereas those that are more likely to have become more broadly expressed have lower enrichment. This finding is consistent with a model in which Alus accumulate near broadly expressed genes but do not affect their expression breadth. Furthermore this model is consistent with the finding that expression breadth of mouse genes predicts Alu density .
