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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Evidence for horizontal transfer of a secondary metabolite gene cluster between fungi. | Open Access Research Evidence for horizontal transfer of a secondary metabolite gene cluster between fungi Nora KhaldiH Jerome CollemareH Marc-Henri Lebrun and Kenneth H Wolfe Addresses Smurfit Institute of Genetics Trinity College Dublin Dublin 2 Ireland. t2UMR5240 CNRS UCB INSA BCS Bayer Cropscience 69263 Lyon cedex 09 France. H These authors contributed equally to this work. Correspondence Kenneth H Wolfe. Email khwolfe@tcd.ie Published 24 January 2008 Genome Biology 2008 9 R18 doi 10.1186 gb-2008-9-1-r18 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2008 9 1 R18 Received 9 October 2007 Revised 21 December 2007 Accepted 24 January 2008 2008 Khaldi et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Filamentous fungi synthesize many secondary metabolites and are rich in genes encoding proteins involved in their biosynthesis. Genes from the same pathway are often clustered and co-expressed in particular conditions. Such secondary metabolism gene clusters evolve rapidly through multiple rearrangements duplications and losses. It has long been suspected that clusters can be transferred horizontally between species but few concrete examples have been described so far. Results In the rice blast fungus Magnaporthe grisea the avirulence gene ACE that codes for a hybrid polyketide synthase-nonribosomal peptide synthetase PKS-NRPS belongs to a cluster of 15 genes involved in secondary metabolism. Additional related clusters were detected in the ascomycetes Chaetomium globosum Stagonospora nodorum and Aspergillus clavatus. Gene-by-gene phylogenetic analysis showed that in C. globosum and M. grisea the evolution of these ACE -like clusters is .
