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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: The distributions, mechanisms, and structures of metabolite-binding riboswitches. | Reseirch The distributions mechanisms and structures of metabolite-binding riboswitches Jeffrey E Barrick and Ronald R Breaker Open Access Addresses Department of Molecular Biophysics and Biochemistry Yale University New Haven Connecticut 06520-8103 USA. Department of Microbiology and Molecular Genetics Michigan State University East Lansing MI48824-4320 USA. Howard Hughes Medical Institute Yale University New Haven Connecticut 06520-8103 USA. Department of Molecular Cellular and Developmental Biology Yale University New Haven Connecticut 06520-8103 USA. Correspondence Ronald R Breaker. Email ronald.breaker@yale.edu Received 26 July 2007 Revised l October 2007 Accepted 12 November 2007 Published 12 November 2007 Genome Biology 2007 8 R239 doi l0.ll86 gb-2007-8-ll-r239 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2007 8 ll R239 2007 Barrick and Breaker licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Riboswitches are noncoding RNA structures that appropriately regulate genes in response to changing cellular conditions. The expression of many proteins involved in fundamental metabolic processes is controlled by riboswitches that sense relevant small molecule ligands. Metabolite-binding riboswitches that recognize adenosylcobalamin AdoCbl thiamin pyrophosphate TPP lysine glycine flavin mononucleotide FMN guanine adenine glucosamine-6-phosphate GlcN6P 7-aminoethyl 7-deazaguanine preQl and S-adenosylmethionine SAM have been reported. Results We have used covariance model searches to identify examples of ten widespread riboswitch classes in the genomes of organisms from all three domains of life. This data set rigorously defines the phylogenetic .
