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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: The determinants of gene order conservation in yeasts. | Open Access Research The determinants of gene order conservation in yeasts Juan F Poyatos and Laurence D HursL Addresses Logic of Genomic Systems Laboratory Spanish National Biotechnology Centre Centro Superior de Investigaciones Cientificas CSIC Darwin 3 Campus de Cantoblanco Madrid 28049 Spain. Department of Biology and Biochemistry University of Bath Bath BA2 7AY UK. Correspondence Juan F Poyatos. Email jpoyatos@cnb.uam.es Published 5 November 2007 Genome Biology 2007 8 R233 doi 10.1186 gb-2007-8-11-r233 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2007 8 11 R233 Received 10 July 2007 Revised 1 2 September 2007 Accepted 5 November 2007 2007 Poyatos and Hurst licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Why do some groups of physically linked genes stay linked over long evolutionary periods Although several factors are associated with the formation of gene clusters in eukaryotic genomes the particular contribution of each feature to clustering maintenance remains unclear. Results We quantify the strength of the proposed factors in a yeast lineage. First we identify the magnitude of each variable to determine linkage conservation by using several comparator species at different distances to Saccharomyces cerevisiae. For adjacent gene pairs in line with null simulations intergenic distance acts as the strongest covariate. Which of the other covariates appear important depends on the comparator although high co-expression is related to synteny conservation commonly especially in the more distant comparisons these being expected to reveal strong but relatively rare selection. We also analyze those pairs that are immediate neighbors through
