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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài:Characterization of heterotypic interaction effects in vitro to deconvolute global gene expression profiles in cancer. | Research Open Access Characterization of heterotypic interaction effects in vitro to deconvolute global gene expression profiles in cancer Martin Buess Dimitry SA Nuyten Trevor Hastie Torsten Nielsen Robert Pesich and Patrick O Brown Addresses Department of Biochemistry Stanford University School of Medicine Stanford CA 94305 USA. Department of Statistics Stanford University School of Medicine Stanford CA 94305 USA. Howard Hughes Medical Institute Stanford University School of Medicine Stanford CA 94305 USA. Departments of Radiation Oncology and Diagnostic Oncology Netherlands Cancer Institute 1066 CX Amsterdam The Netherlands. Department of Pathology and Laboratory Medicine University of British Columbia Vancouver BC Canada V5Z 1M9. Correspondence Patrick O Brown. Email pbrown@pmgm2.stanford.edu Published 14 September 2007 Genome Biology 2007 8 R191 doi l0.ll86 gb-2007-8-9-rl9l The electronic version of this article is the complete one and can be found online at http genomebiology.com 2007 8 9 Rl9l Received 26 March 2007 Revised 14 June 2007 Accepted 14 September 2007 2007 Buess et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Perturbations in cell-cell interactions are a key feature of cancer. However little is known about the systematic effects of cell-cell interaction on global gene expression in cancer. Results We used an ex vivo model to simulate tumor-stroma interaction by systematically cocultivating breast cancer cells with stromal fibroblasts and determined associated gene expression changes with cDNA microarrays. In the complex picture of epithelial-mesenchymal interaction effects a prominent characteristic was an induction of interferon-response genes IRGs in a subset of cancer cells. .
