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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: No agreement of mixed venous and central venous saturation in sepsis, independent of sepsis origin. | van Beest et al. Critical Care 2010 14 R219 http ccforum.eom content 14 6 R219 KS CRITICAL CARE RESEARCH Open Access No agreement of mixed venous and central venous saturation in sepsis independent of sepsis origin D-i I A rz D o o I- 4- 11 -V 1 t V I f- t 2 E L r I r I D V V I s 3 I I r I o I_I z I LZ-V-X s .2 I_lz k xlz ClrrirỊ k 4 IV ỉ -sTTx r l z .z . k m r 3 Paul A van Beest Jan van Ingen E Christiaan Boerma Nicole D Holman HenK Groen Matty Koopmans Peter E SpronK5 6 Michael A Kuiper3 6 Abstract Introduction Controversy remains regarding the relationship between central venous saturation ScvO2 and mixed venous saturation SvO2 and their use and interchangeability in patients with sepsis or septic shock. We tested the hypothesis that ScvO2 does not reliably predict SvO2 in sepsis. Additionally we looked at the influence of the source splanchnic or non-splanchnic of sepsis on this relationship. Methods In this prospective observational two-center study we concurrently determined ScvO2 and SvO2 in a group of 53 patients with severe sepsis during the first 24 hours after admission to the intensive care units in 2 Dutch hospitals. We assessed correlation and agreement of ScvO2 and SvO2 including the difference i.e. the gradient between ScvO2 and SvO2 ScvO2 - SvO2 . Additionally we compared the mean differences between ScvO2 and SvO2 of both splanchnic and non-splanchnic group. Results A total of 265 paired blood samples were obtained. ScvO2 overestimated SvO2 by less than 5 with wide limits of agreement. For changes in ScvO2 and SvO2 results were similar. The distribution of the ScvO2 - SvO2 0 or 0 was similar in survivors and nonsurvivors. The mean ScvO2 - SvO2 in the splanchnic group was similar to the mean ScvO2 - SvO2 in the non-splanchnic group 0.8 3.9 vs. 2.5 6.2 P 0.30 . O2ER P 0.23 and its predictive value for outcome P 0.20 were similar in both groups. Conclusions ScvO2 does not reliably predict SvO2 in patients with severe sepsis. The trend of ScvO2 is not
