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Glutathione peroxidases (EC 1.11.1.9 and EC 1.11.1.12) catalyze the reduc-tion of H2O2or organic hydroperoxides to water or corresponding alcohols using reduced glutathione. Some glutathione peroxidase isozymes have a selenium-dependent glutathione peroxidase activity and present a selenocy-steine encoded by the opal TGA codon. | ỊFEBS Journal Glutathione peroxidase family - an evolutionary overview Rogerio Margis1 Christophe Dunand2 Felipe K. Teixeira3 and Marcia Margis-Pinheiro1 4 1 Centro de Biotecnologia Universidade Federaldo Rio Grande do Sul Porto Alegre Brazil 2 Laboratory of Plant Physiology University of Geneva Switzerland 3 Departamento de Genetica Universidade Federaldo Rio de Janeiro Brazil 4 Departmento de Genetica Universidade Federaldo Rio Grande do Sul Porto Alegre Brazil Keywords evolution glutathione peroxidase peroxiredoxins subcellular location thioredoxin Correspondence M. Margis-Pinheiro Departamento de Genetica Universidade Federaldo Rio Grande do Sul Sala 207 Predio 43312 91501-970 Porto Alegre Brazil Fax 55 51 3308 7311 Tel 55 51 3308 9814 E-mail marcia.margis@ufrgs.br Present address Unite de Recherche en Genomique Végétale INRA-CNRS-UEVE Evry Cedex France Received 4 March 2008 revised 20 May 2008 accepted 6 June 2008 Glutathione peroxidases EC 1.11.1.9 and EC 1.11.1.12 catalyze the reduction of H2O2 or organic hydroperoxides to water or corresponding alcohols using reduced glutathione. Some glutathione peroxidase isozymes have a selenium-dependent glutathione peroxidase activity and present a selenocysteine encoded by the opal TGA codon. In the present study insights into the evolution of the whole glutathione peroxidase gene family were obtained after a comprehensive phylogenetic analysis using the improved number of glutathione peroxidase sequences recorded in the PeroxiBase database http peroxidase.isb-sib.ch index.php . The identification of a common ancestral origin for the diverse glutathione peroxidase clusters was not possible. The complex relationships and evolutionary rates of this gene family suggest that basal glutathione peroxidase classes present in all kingdoms have originated from independent evolutionary events such as gene duplication gene losses lateral gene transfer among invertebrates and vertebrates or plants. In addition the present study .
