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For decades, endocytosis has been recognized as a fundamental cellular process that regulates the uptake of small molecules (cell surface proteins, bacteria, toxins, etc.) into the cell. So why, after years of study, does this simple process warrant more discussion? Anyone who has examined the endocytic pathway will appreciate that this conceptually simple mechanism is highly complex and sophisticated. Like ballet dancers who make their synchronous performance seem effortless, the cell brings in molecules via a carefully choreographed mechanism. However, closer inspection reveals very specific roles that are dependent on the cargo being internalized. There are differences in the routes of entry into the cell (calthrin-mediated versus nonclathrin dependent),. | Brian Ceresa Molecular Regulation of Endocytosis MOLECULAR REGULATION OF ENDOCYTOSIS Edited by Brian Ceresa Molecular Regulation of Endocytosis http dx.doi.org 10.5772 2989 Edited by Brian Ceresa Contributors Frauke Ackermann Joshua A. Gregory Lennart Brodin Abbas A. Alibhoy Hui-Ling Chiang Ichirou Karahara L. Andrew Staehelin Yoshinobu Mineyuki Jianjun Sun Jesse S. Aaron Jerilyn A. Timlin Paola Ramoino Alberto Diaspro Marco Fato Cesare Usai Norica Branza-Nichita Alina Macovei Catalin Lazar F. Brent Johnson Enkhmart Dudleenamjil Maude Boisvert Peter Tijssen Thorsten Eierhoff Bahne Stechmann Winfried Romer Maria C. Touz Zhixiang Wang Elisa Sala Luca Ruggiero Giuseppina Di Giacomo Ottavio Cremona Ronny Racine Mark E. Mummert Johan A. Slotman Peter van Kerkhof Gerco Hassink Hendrik J. Kuiken Ger J. Strous Keiji Hirota Hiroshi Terada Wanling Liang Jenny K. W. Lam Published by InTech Janeza Trdine 9 51000 Rijeka Croatia Copyright 2012 InTech All chapters are Open Access distributed under the Creative Commons Attribution 3.0 license which allows users to download copy and build upon published articles even for commercial purposes as long as the author and publisher are properly credited which ensures maximum dissemination and a wider impact of our publications. After this work has been published by InTech authors have the right to republish it in whole or part in any publication of which they are the author and to make other personal use of the work. Any republication referencing or personal use of the work must explicitly identify the original source. Notice Statements and opinions expressed in the chapters are these of the individual contributors and not necessarily those of the editors or publisher. No responsibility is accepted for the accuracy of information contained in the published chapters. The publisher assumes no responsibility for any damage or injury to persons or property arising out of the use of any materials instructions methods or ideas contained in the
